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To be close from both the nightlife and the tourist sites, stay in the downtown area near the Sule Pagoda.
One of the poshest neighborhoods in Yangon, it is also where you'll find the trendiest nightclubs and bars.
They can be found in the brand new mall Myanmar Plaza (Fuse, Eclipse, Harry's), in Kabar Aye Road (Cask 81, The West) or in Kanbawza Street (Genki Kids, Porter House and a few more fine dining restaurants). This is not exactly a nightlife area, but you have several rooftop bars and cafés targeting tourists and locals. Vista and The Penthouse have a beautiful view on Shwedagon Pagoda. On the main road, you may encounter ladyboys looking for customers.
→ → Tinder: Very limited unless you want to meet tourists/expats → Asia Dating: Some English-speaking profiles, you can check who's online by making a free account here.