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Abstracts from the International Research Workshops on eczema and itch, the conference proceedings of the European Academy of Dermatology and Venereology, and of the European Academy of Allergy and Clinical Immunology from 2000 to 2011 were screened, in order to identify further potentially relevant RCTs (EJv Z, UM, and EW). Four review authors independently assessed the titles and abstracts for eligible RCTs (CJA, EJv Z, ZF and AJ).

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This is a summary of a Cochrane systematic review that was conducted to assess the effects of oral antihistamines (H1 antagonists) as monotherapy in children and adults with eczema [).

The bibliographies of the excluded studies were examined for further references to potentially eligible RCTs (EJv Z) and two review authors searched for ongoing and unpublished trials in January 2014 (EJv Z and UM).

Therefore, the nomenclature review committee of the World Allergy Organization has proposed the use of "eczema" as a unifying term, and this term is also used throughout the text of this review [].

Although the exact role of histamine in itch still needs to be elucidated and it remains unclear if oral antihistamines are effective in the management of eczema, they continue to be prescribed by physicians.

In older children and adults, areas of involvement are usually the hands, neck, inner elbows, behind the knees and the ankles. Although it typically becomes less severe as one becomes older, it is a lifelong condition which waxes and wanes.