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These changes in pinopode expression may reflect shifts in the window of receptivity, resulting in ovo-endometrial asynchrony and limiting implantation success in in-vitro fertilization.

Key words: endometrial pinopodes/implantation/IVF/nidation window/uterine receptivity Citation Context ..a commercially available urine kit (Ovu Quick, Quidel, San Diego, CA, USA), and validated by dates of onset of the next menstrual period and histological dating according to morphological criteria (=-=Noyes et al., 1950-=-). Implantation in humans is a complex process that involves embryo apposition and attachment to the maternal endometrial epithelium, traversing adjacent cells of the epithelial lining, and invasion into the endometrial stroma.

However, research on relevant animal and in-vitro models as well as studies on human endometrium and in-vitro embryos, allow some indirect insights to this phenomenon.

This review summarizes information on cell-surface morphological events relevant to implantation initiation, derived from scanning electron micro-scopy studies on the above systems.

Looking at the curves representing several cellular features, such as mitoses, pseudostratification of nuclei, basal ... 3To whom correspondence should be addressed The formation of endometrial pinopodes detected by scanning electron microscopy may be a specific marker for uterine receptivity.