As a teenager, she relocated to Los Angeles with her mother, and made her television debut in In Search of the New Partridge Family (2004), a reality show that produced only an unsold pilot.
After small television roles, she made her film debut in Superbad (2007), and received positive media attention for her role in Zombieland (2009).
Stone gained wider recognition for playing Gwen Stacy in the 2012 superhero film The Amazing Spider-Man, and its sequel in 2014.
She was nominated for an Academy Award for Best Supporting Actress for the role of a recovering drug addict in the black comedy-drama Birdman (2014).
Loosely based on Charles Dickens' 1843 novella A Christmas Carol, the romantic comedy has her playing a ghost who haunts her former boyfriend.