for which she was nominated for a Young Artist Award. In 1998 she appeared in the John Waters film Pecker. The 1999 film 200 Cigarettes received generally negative reviews, but the All Movie reviewer wrote of Plimpton: "...woefully underappreciated Martha Plimpton gets laughs as a bundle of neuroses who grows more and more stressed out as people fail to appear for her party..." She co-founded a production company, Everything is Horrible, which has produced short films for the Internet.
In her late teenage years, Plimpton was also active in theater, performing in regional theater in Seattle, Washington, where her mother was living at the time. Plimpton received her second nomination for a Tony Award in 2008, Best Performance by a Featured Actress In a Play, for her work in Top Girls at the Biltmore Theater.
Plimpton sang "God Bless America" during the seventh inning stretch of Game 3 of the 2010 World Series in Texas on Fox, October 30, 2010.
In 2014, Plimpton returned to Broadway as Julia, the daughter of Glenn Close and John Lithgow in a revival of Edward Albee's A Delicate Balance.
Her performance, well received by critics, included songs "Jolly Coppers on Parade", "Woman Is the Nigger of the World", and The Smiths's "Ask" tied together with humorous monologues.